Faithful advocates: faith communities and environmental activism in Scotland

This thesis investigates local-level environmental activism in faith communities, and aims to understand what explains environmental advocacy by Christian faith communities. It asks why Christian communities are participating in environmental advocacy, and identifies the motivations and practices behind their engagement. Faith-based organisations and faith communities are increasingly active in environmental advocacy, both through high-level interventions, and local-level action. While high-level engagement often attracts widespread attention, as in the case of the Pope’s 2015 environmentally-focused encyclical, the engagement of locally-grounded faith communities is often overlooked, both in academia and practice. This thesis aims to fill that void by exploring faith-based environmentalism from the perspective of the local faith community. It takes an ethnographic approach, based on twelve months of participant observation in three Christian congregations in Edinburgh engaged in environmental action. Building on earlier studies of religion and ecology and religious environmentalism, this thesis argues that environmental engagement is explained by theological motivations, and also by practical factors expressed and experienced in the social context of the local faith community. Theologically, faith communities base their environmental engagement within a broad framework of justice, understanding the natural environment as God’s creation, and aligning a Christian responsibility to ‘care for creation’ with recognition of the impacts of climate change and environmental degradation on those least equipped to respond. Yet theology alone cannot explain this advocacy. Engagement is motivated by a sense of community and, more pragmatically, is also explained by everyday issues that reflect the reality of life in a faith community. It is in the social context of the faith community that these factors are brought together. Above all, the research findings emphasise the importance of community, understood both as people and place, as a key underlying factor explaining engagement. By highlighting the central role of community in environmental advocacy, this thesis offers insight into religious environmentalism that prioritises the everyday, ‘lived’ experience of religion, and articulates the importance of the social context in which religion is practiced for understanding engagement

The value of listening and listening for values in conservation

Listening is a pervasive and significant act of conservation research and praxis, mattering greatly for the realisation of conservation agendas, not least its ambitions to be outward looking and inclusive in approach. Yet, the value and role of listening has been barely explored in a sustained and reflexive way. This paper is a preliminary schematic of what it might mean to attend to the act of listening, set within the context of a larger field of listening scholarship as well as more specific manoeuvres to embed relational approaches into the study of people and nature interactions. We explore what it means to 'listen well' within the context of conservation, highlighting the importance of recognising listening as a relationship and our positions and power within those relationships; the need to care for the relationship through respect and empathy; and the building of inclusive relationships of listening by attending to how space and time influences understanding. We offer examples of how researchers and practitioners can create spaces for listening, illustrating our discussion with personal reflections about listening practices gained through our various conservation and research careers. We provide approaches and ideas which help the reader—academic and practitioner—to both understand and articulate the value of listening in conservation and relational values of nature. We hope to inspire the wider use of listening-based approaches in conservation research and practice, and the recognition and support from senior managers and funders of what is needed to promote long-term and meaningful relationships between people and nature

Conservation in conversation: People's perspectives on a woodland with high conservation value-A qualitative study

Concepts such as ecosystem services and nature's contributions to people are frameworks for articulating the value of nature and biodiversity conservation. Yet it remains difficult to argue for the conservation of species and habitats where they are inconspicuous or 'non-charismatic'. This paper investigates the perceptions of a woodland area in rural western Scotland, designated for its high conservation value and characterised by habitats, rare species and species assemblages with limited appreciation by non-experts and no obvious 'utility' value. Based on interviews with residents and visitors as well as workshops with participants representing different types of local expertise, we show how people experience and perceive the benefits from such woodlands. Overall, our study participants emphasised values and ecosystem services that benefitted humans, strongly drawing on stories of cultural or historical land use to argue for more material opportunities to be created. For those participants without ecological expertise, the designated conservation value, albeit respected and accepted, remained vague and bland. Participants also articulated a strong underlying development logic, pushing in some way for 'more' to be made from the woodlands so that more people could receive benefits from the woodland either directly (e.g. mental restoration; increased use for recreation) or indirectly (e.g. through creating jobs in the local tourism industry). Our findings suggest that managing for conservation alone might cause challenges in acceptability, especially where the species and habitats conserved are of little obvious value to the non-specialist. At the same time, participants recognised that they valued the woodland being unique in some way, and that increasing the material use of the woods might harm the very essence of what made it special

Climate Change Engagement – Assessing the Impacts of the Climate Challenge Fund

The Scottish Government established the Climate Challenge Fund (CCF) in 2008 to help local communities in the transition to a low-carbon society. The fund supports community-led projects which lead to reductions in carbon emissions, and which are designed to leave a sustainable legacy of low-carbon behaviour. It works in areas such as energy efficiency, sustainable and active travel, reducing and recycling waste, and food growing. As of mid-2020, over 1,150 projects across all Scotland’s 32 local authorities had been awarded CCF grants, with total funding since 2008 exceeding £111 million. This report considers the evidence for the fund’s impact on the ground, the actions that were (and perhaps not) effective and how we can monitor success in the future. The research centres on in-depth case studies of five CCF projects which the team followed for 18 months. The report uses the case study evidence to understand and capture the processes of change supported by the CCF. From this, it draws out lessons on how to facilitate and monitor such impact going forward

"Give me some space" : exploring youth to parent aggression and violence

A small scale qualitative project, undertaken by an interdisciplinary domestic violence research group involving academic researchers and research assistants, with colleagues from Independent Domestic Abuse Services (IDAS), investigated youth aggression and violence against parents. Following the literature review, data was generated through several research conversations with young people (n = 2), through semi-structured interviews with mothers (n = 3) and practitioners (n = 5), and through a practitioner focus group (n = 8). Thematic analysis and triangulation of the data from parents, practitioners and young people, elicited interconnected and complex overarching themes. Young people could be both victim and perpetrator. The witnessing or experiencing of domestic aggression and violence raised the concept of ‘bystander children’. The impact of young people experiencing familial violence was underestimated by parents. For practitioners, the effects of working with domestic violence was shown to be significant - both positively and negatively

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements.

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5-2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility

Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease

Olfactory receptors (ORs) and down-stream functional signaling molecules adenylyl cyclase 3 (AC3), olfactory G protein \u3b1 subunit (G\u3b1olf), OR transporters receptor transporter proteins 1 and 2 (RTP1 and RTP2), receptor expression enhancing protein 1 (REEP1), and UDP-glucuronosyltransferases (UGTs) are expressed in neurons of the human and murine central nervous system (CNS). In vitro studies have shown that these receptors react to external stimuli and therefore are equipped to be functional. However, ORs are not directly related to the detection of odors. Several molecules delivered from the blood, cerebrospinal fluid, neighboring local neurons and glial cells, distant cells through the extracellular space, and the cells' own self-regulating internal homeostasis can be postulated as possible ligands. Moreover, a single neuron outside the olfactory epithelium expresses more than one receptor, and the mechanism of transcriptional regulation may be different in olfactory epithelia and brain neurons. OR gene expression is altered in several neurodegenerative diseases including Parkinson's disease (PD), Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and sporadic Creutzfeldt-Jakob disease (sCJD) subtypes MM1 and VV2 with disease-, region- and subtype-specific patterns. Altered gene expression is also observed in the prefrontal cortex in schizophrenia with a major but not total influence of chlorpromazine treatment. Preliminary parallel observations have also shown the presence of taste receptors (TASRs), mainly of the bitter taste family, in the mammalian brain, whose function is not related to taste. TASRs in brain are also abnormally regulated in neurodegenerative diseases. These seminal observations point to the need for further studies on ORs and TASRs chemoreceptors in the mammalian brain

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.

BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare disease with an emerging genetic basis. Heterozygous mutations in the gene encoding the bone morphogenetic protein receptor type 2 (BMPR2) are the commonest genetic cause of PAH, whereas biallelic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF2AK4) are described in pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis. Here, we determine the frequency of these mutations and define the genotype-phenotype characteristics in a large cohort of patients diagnosed clinically with PAH. METHODS: Whole-genome sequencing was performed on DNA from patients with idiopathic and heritable PAH and with pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis recruited to the National Institute of Health Research BioResource-Rare Diseases study. Heterozygous variants in BMPR2 and biallelic EIF2AK4 variants with a minor allele frequency of <1:10 000 in control data sets and predicted to be deleterious (by combined annotation-dependent depletion, PolyPhen-2, and sorting intolerant from tolerant predictions) were identified as potentially causal. Phenotype data from the time of diagnosis were also captured. RESULTS: Eight hundred sixty-four patients with idiopathic or heritable PAH and 16 with pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis were recruited. Mutations in BMPR2 were identified in 130 patients (14.8%). Biallelic mutations in EIF2AK4 were identified in 5 patients with a clinical diagnosis of pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis. Furthermore, 9 patients with a clinical diagnosis of PAH carried biallelic EIF2AK4 mutations. These patients had a reduced transfer coefficient for carbon monoxide (Kco; 33% [interquartile range, 30%-35%] predicted) and younger age at diagnosis (29 years; interquartile range, 23-38 years) and more interlobular septal thickening and mediastinal lymphadenopathy on computed tomography of the chest compared with patients with PAH without EIF2AK4 mutations. However, radiological assessment alone could not accurately identify biallelic EIF2AK4 mutation carriers. Patients with PAH with biallelic EIF2AK4 mutations had a shorter survival. CONCLUSIONS: Biallelic EIF2AK4 mutations are found in patients classified clinically as having idiopathic and heritable PAH. These patients cannot be identified reliably by computed tomography, but a low Kco and a young age at diagnosis suggests the underlying molecular diagnosis. Genetic testing can identify these misclassified patients, allowing appropriate management and early referral for lung transplantation

Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease

Inherited retinal disease is a common cause of visual impairment and represents a highly heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals with inherited retinal disease, who have had whole-genome sequencing (n = 605), whole-exome sequencing (n = 72), or both (n = 45) performed, as part of the NIHR-BioResource Rare Diseases research study. We identified pathogenic variants (single-nucleotide variants, indels, or structural variants) for 404/722 (56%) individuals. Whole-genome sequencing gives unprecedented power to detect three categories of pathogenic variants in particular: structural variants, variants in GC-rich regions, which have significantly improved coverage compared to whole-exome sequencing, and variants in non-coding regulatory regions. In addition to previously reported pathogenic regulatory variants, we have identified a previously unreported pathogenic intronic variant in $\textit{CHM}$ in two males with choroideremia. We have also identified 19 genes not previously known to be associated with inherited retinal disease, which harbor biallelic predicted protein-truncating variants in unsolved cases. Whole-genome sequencing is an increasingly important comprehensive method with which to investigate the genetic causes of inherited retinal disease.This work was supported by The National Institute for Health Research England (NIHR) for the NIHR BioResource – Rare Diseases project (grant number RG65966). The Moorfields Eye Hospital cohort of patients and clinical and imaging data were ascertained and collected with the support of grants from the National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital, National Health Service Foundation Trust, and UCL Institute of Ophthalmology, Moorfields Eye Hospital Special Trustees, Moorfields Eye Charity, the Foundation Fighting Blindness (USA), and Retinitis Pigmentosa Fighting Blindness. M.M. is a recipient of an FFB Career Development Award. E.M. is supported by UCLH/UCL NIHR Biomedical Research Centre. F.L.R. and D.G. are supported by Cambridge NIHR Biomedical Research Centre